- Merck KGaA, Darmstadt, Germany, to feature new research from marketed and pipeline compounds
- Preliminary results from combination study with avelumab in renal cell carcinoma, and updates on Phase II tepotinib program in non-small cell lung cancer, to be presented
- Merck KGaA, Darmstadt, Germany, to announce 2016 Grant for Oncology Innovation winners coinciding with ESMO
Merck KGaA, Darmstadt, Germany, a leading science and technology company, today announced that new research from their marketed and pipeline compounds will be presented at this year's European Society for Medical Oncology (ESMO; October 7-11, 2016, Copenhagen, Denmark) annual meeting. Presentations will focus on hard-to-treat cancers, and include: study results for Erbitux(R) (cetuximab) in metastatic colorectal cancer (mCRC) and squamous cell carcinoma of the head and neck (SCCHN); preliminary study results in bladder cancer and renal cell carcinoma (RCC) for avelumab, which is being developed in collaboration with Pfizer; and updates on the Phase II program for tepotinib* in non-small cell lung cancer (NSCLC).
"The data being presented at ESMO reflect our commitment to making a meaningful difference in patients' lives, in particular those who are affected by hard-to-treat cancers," said Luciano Rossetti, Executive Vice President, Head of Global Research & Development at the biopharma business of Merck KGaA, Darmstadt, Germany. "We continue to focus on researching the full potential of Erbitux, as well as our ongoing pipeline development programs for avelumab and other early-stage oncology and immune-oncology compounds."
At ESMO, avelumab will be featured in four posters that add to the growing body of evidence of the potential of this investigational compound. These will include data updates in bladder cancer that confirm avelumab's potential in this hard-to-treat cancer; and preliminary results from a combination study with axitinib in RCC that support the rationale to evaluate the combination in a Phase III pivotal study. Tepotinib, a highly selective c-Met kinase inhibitor, will also be highlighted in three posters, with updates on the ongoing study program in c-Met-positive metastatic NSCLC.
Several studies, which will be presented at ESMO, once again reaffirm Erbitux as a standard-of-care therapy for mCRC patients with RAS wild-type tumors and patients with SCCHN.
Merck KGaA, Darmstadt, Germany, believes that to truly deliver the promise of innovation for patients, it is vital to support and encourage research from other endeavors. This is demonstrated through Merck KGaA, Darmstadt, Germany's Grant for Oncology Innovation (GOI) initiative, which awards researchers for their pioneering independent work in pushing the boundaries of creativity and science in order to deliver transformative innovation. The award ceremony will once again coincide with ESMO and takes place on Sunday, October 9, 2016.
*Tepotinib is the proposed nonproprietary name for the c-Met kinase inhibitor (also known as MSC2156119J).
Avelumab and tepotinib are under clinical investigation and have not been proven to be safe and effective. There is no guarantee any product will be approved in the sought-after indication by any health authority worldwide.
Notes to Editors
Accepted Merck KGaA, Darmstadt, Germany-supported abstracts are listed below. In addition, a number of investigator-sponsored studies have been accepted, including several related to Erbitux (not listed).
Title Lead Abstract Presentation Session Room/
Author # date/time Details
(CDT)
Erbitux
Impact of tumor S Qin 527P October 8 Poster Display Hall E
epidermal growth factor 13:00-14:00 Session
receptor (EGFR) status
on the outcomes of
first-line FOLFOX-4
plus or minus cetuximab
in patients (pts) with
RAS-wild-type (wt)
metastatic colorectal
cancer (mCRC) in the
randomized phase 3
TAILOR trial
Impact of surgical U Neumann 491P October 8 Poster Display Hall E
resection of liver 13:00-14:00 Session
metastases on outcome
of patients with
metastatic colorectal
carcinoma (mCRC)
treated with a
cetuximab-based
first-line therapy -
Analysis of the
KRAS-wildtype exon 2
(KRAS-wt) subgroup of
the German
non-interventional
study ERBITAG
Observational study of J Guigay 967P October 9 Poster Display Hall E
the dose intensity 13:00-14:00 Session
relative to cetuximab
in the first-line
treatment of recurrent
and/or metastatic
squamous cell carcinoma
of the head and neck:
data on the maintenance
and bi-weekly use
(DIRECT study)
Cetuximab in M Hecht 994P October 9 Poster Display Hall E
combination with 13:00-14:00 Session
platinum-based
chemotherapy or
radiotherapy in
recurent and/or
metastatic SCCHN in a
non-selected patient
cohort (interim
analysis of the phase
IV SOCCER trial)
Title Lead Abstract Presentation Session Room/
Author # date/time Details
(CDT)
Avelumab
Avelumab (MSB0010718C; M Patel 777PD October 9 Poster Athens
anti-PD-L1) in patients 16:30-17:30 Discussion
with metastatic Session
urothelial carcinoma Genitourinary
progressed after tumors, non-
platinum-based therapy prostate
or platinum ineligible
Phase 1b dose-finding Poster Athens
study of avelumab J Larkin 775PD October 9 Discussion
(anti-PD-L1) + axitinib 16:30-17:30 Session
in treatment-na?ve Genitourinary
patients with advanced tumors, non-
renal cell carcinoma prostate
Evaluation of real J Becker 1154P October 9 Poster Display Hall E
world treatment 13:00-14:00 Session
outcomes in patients
with metastatic Merkel
cell carcinoma (MCC)
following second line
chemotherapy
A multicenter, T Powles 842TiP October 9 Poster Display Hall E
international, 13:00-14:00 Session
randomized, open-label
phase 3 trial of
avelumab + best
supportive care (BSC)
vs BSC alone as
maintenance therapy
after first-line
platinum-based
chemotherapy in
patients with advanced
urothelial cancer
(JAVELIN Bladder 100)
Phase 3 study of R Motzer 844TiP October 9 Poster Display Hall E
avelumab in combination 13:00-14:00 Session
with axitinib versus
sunitinib as first-line
treatment for patients
with advanced renal
cell carcinoma (aRCC)
Title Lead Abstract Presentation Session Room/
Author # date/time Details
(CDT)
Tepotinib
Tepotinib plus Y-L Wu 1257P October 8 Poster Display Hall E
gefitinib in patients 13:00-14:00 Session
with
c-Met-positive/EGFR-mut
ant NSCLC: recommended
phase II dose (RP2D),
tolerability, and
efficacy
Design of a phase II Y-L Wu 1287TiP October 8 Poster Display Hall E
trial comparing 13:00-14:00 Session
tepotinib + gefitinib
with cisplatin +
pemetrexed in EGFR
inhibitor-resistant,
c-Met+ NSCLC
A phase II trial P Paik 1292TiP October 8 Poster Display Hall E
investigating the 13:00-14:00 Session
highly selective c-Met
inhibitor tepotinib in
stage IIIB/IV lung
adenocarcinoma with MET
exon 14 alterations
after failure of at
least one prior therapy
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