New findings from an indirect comparison between Xultophy(R) and IGlarLixi published in the Journal of Medical Economics show that treatment with Xultophy(R) (insulin degludec/liraglutide) provides statistically significant greater reductions in blood sugar levels and body weight compared with IGlarLixi (insulin glargine U100/lixisenatide), in people with type 2 diabetes who struggle to achieve desired blood sugar targets with basal insulin alone.[1]
"In the absence of a head-to-head trial between Xultophy(R) and IGlarLixi, the solid methodology of this indirect comparison, where we adjusted for key differences between study designs and patient populations, allows us to conclude that Xultophy(R) can deliver greater reductions in the overall blood sugar levels and weight for people with type 2 diabetes who are uncontrolled on basal insulin, compared to IGlarLixi," said lead study author Professor Marc Evans of University Hospital, Llandough in Cardiff, UK. "This analysis is based on published data from individual clinical trials which involved over 700 adults living with type 2 diabetes."
This indirect comparison showed that, within the study population, people with type 2 diabetes uncontrolled on basal insulin achieved a 0.44% greater reduction of their overall blood sugar levels (HbA1c), and a 1.42 kg greater weight loss when treated with Xultophy(R) , compared to those treated with IGlarLixi, at similar doses of insulin. Additionally, the analysis found a higher likelihood of reaching target blood sugar levels (HbA1c <7%) with Xultophy(R), compared to IGlarLixi.[1]
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